Unconventional methods

Name	Pub date	Instrument	Specificity
MMA [1]	2016 June	Synapt G2-Si/Xevo G2-XS	Data-driven isolation window optim
DDIA [2]	2020 June	Fusion	Insert DD scans into each cycle
DI-SPA [3]	2020 Nov.	Lumos+FAIMS	Direct infusion + FAIMS
Hybrid-DIA [4]	2023 June	Exploris 480	Triggered targeted analysis

Note

• Pub date: the date the method was publicly released by publisher

• Instrument: initially developped on which instrument

Individuals

MMA

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Reference:

[1]

Multi-mode acquisition (MMA): An MS/MS acquisition strategy for maximizing selectivity, specificity and sensitivity of DIA product ion spectra. 10.1002/pmic.201500492

Full name	multi-mode acquisition
Authors	Brad J. Williams et al.
Lab & Company	Waters Corporation
Publication date	2016, June
MS instrument	Synapt G2-Si, Xevo G2-XS QTof

DDIA

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Reference:

[2]

Data Dependent-Independent Acquisition (DDIA) Proteomics. 10.1021/acs.jproteome.0c00186

Full name	Data Dependent-Independent Acquisition
Authors	Shenheng Guan et al.
Lab & Company	Ma Lab
Publication date	2020 June
MS instrument	Orbitrap Fusion

DI-SPA

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Reference:

[3]

Quantitative shotgun proteome analysis by direct infusion. 10.1038/s41592-020-00999-z

Full name	direct infusion-shotgun proteome analysis
Authors	Jesse G. Meyer et al.
Lab & Company	Meyer & Coon Labs
Publication date	2020 Nov.
MS instrument	Orbitrap Fusion Lumos +FAIMS

Hybrid-DIA

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Reference:

[4]

Hybrid-DIA: intelligent data acquisition integrates targeted and discovery proteomics to analyze phospho-signaling in single spheroids. 10.1038/s41467-023-39347-y

Full name	Hybrid-DIA
Authors	Ana Martínez-Val et al.
Lab & Company	Olsen Lab & Thermo Fisher Scientific GmbH
Publication date	2023 June
MS instrument	Exploris 480